Pro-healing, pro-regenerative nanofibrous coating for medical implants
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsParnaz Boodagh, Wei Tan, Michael Floren
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Abstract
The present invention relates to a medical implant, and more particularly, to a vascular implant having a dual coating structure for preventing in-stent restenosis and thrombosis. In one embodiment, the invention contemplates a vascular stent with a coating comprising a hydrophobic, degradable core with a coaxial sheath comprising at least one polyethylene-glycol derivative. In one embodiment, said at least one polyethylene-glycol derivative comprises polyethylene-glycol dimethacrylate.
Claims30
A medical implant with a coating comprising a hydrophobic, degradable core with a coaxial sheath comprising at least one polyethylene-glycol derivative.
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A method of producing a medical implant with a coating, said coating comprising a poly L-lactide acid core with a coaxial sheath comprising polyethylene-glycol dimethacrylate comprising:
- a. providing;
- i. a medical implant;
- ii. poly L-lactide acid;
- and
- iii. polyethylene-glycol dimethacrylate;
- b. combining said poly L-lactide acid and said polyethylene-glycol dimethacrylate under conditions to create a hybrid fiber comprising a poly L-lactide acid core with a coaxial sheath comprising polyethylene-glycol dimethacrylate;
- c. coating said medical implant with said hybrid fiber to create a hybrid fiber coating upon said medical implant;
- and
- d. photo-polymerizing said hybrid fiber coating.
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Dependencies are inferred from the claim text.