Fatty acid-grafted hyaluronic acid, dermal filler formulations comprising same, process for preparation and use thereof
AssigneeMERZ PHARMA GmbH & CO. KGaA
InventorsChristoph HOENNSCHEIDT, Holger KOEHLER
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Abstract
The present invention relates to fatty acid-grafted hyaluronic acid (FA-g-HA), and a sterile microsphere-based dermal filler formulation and a sterile crosslinked hyaluronic acid-based dermal filler formulation each comprising the FA-g-HA. The present invention further relates to processes for the preparation of the FA-g-HA and the dermal filler formulations comprising the FA-g-HA, and their use in cosmetic applications.
Claims15
A fatty acid-grafted hyaluronic acid having a hyaluronic backbone of n repeating disaccharide units with n ranging from 1,250 to 12,500, optionally from 2,500 to 10,000.
The sterile crosslinked hyaluronic acid-based dermal filler formulation of claim 12, wherein the crosslinked HA is present at a concentration of 1 mg/ml to 50 mg/ml and/or wherein the fatty acid-grafted hyaluronic acid is present at a concentration of 0.0001 wt. % to 20 wt. %.
Dependencies are inferred from the claim text.