Styrylbenzothiazole Derivatives and Uses in Imaging Methods

A compound of Formula I:

• or a salt or solvate thereof, wherein:
• n is 1 to 10;
• R1-4 and R12-14 are each independently hydrogen, or an R group selected from, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C4-6 cycloalkyl, hydroxyl, C1-6 hydroxyalkyl, C2-6 hydroxyalkenyl, C2-6 hydroxyalkynyl, thiol, C1-6 thioalkyl, C2-6 thioalkenyl, C2-6 thioalkynyl, C1-6 thioalkoxy, carboxyl, C1-6 carboxyalkyl, halo, C1-6 haloalkyl, C2-6 haloalkenyl, C2-6 haloalkynyl, C1-6 haloalkoxy, amino, C1-6 aminoalkyl, C2-6 aminoalkenyl, C2-6 aminoalkynyl, C1-6 aminoalkoxy, cyano, C1-6 cyanoalkyl, C2-6 cyanoalkenyl, C2-6 cyanoalkynyl, and C1-6 cyanoalkoxy;
• nitro, C1-6 nitroalkyl, C2-6 nitroalkenyl, C2-6 nitroalkynyl, C1-6 nitroalkoxy, and —OCH2OR′, wherein R′ is H or C1-6 alkyl;
• wherein at least one R1-4 comprises an in vivo imaging moiety;
• R5 is hydrogen, C1-6 carboxyalkyl or C1-6 alkyl;
• R6 is halogen, hydroxyl, C1-6 alkoxy, C1-6 alkyl, C2-6 alkenyl, or C2-6 alkynyl;
• and
• wherein at least one R1-6 comprises an in vivo imaging moiety.