Antibody-oligonucleotide conjugates
AssigneeAngiex, Inc.
InventorsPaul A. Jaminet, Shou-Ching S. Jaminet, Edward Ha
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Abstract
Conjugates are provided, comprising a targeting protein, e.g., an anti-TM4SFI antibody or antigen or binding fragments thereof. Methods of manufacture and use of said conjugates are also described.
Claims114
An antibody-RNA conjugate comprising an anti-TM4SF1 antibody or an antigen binding fragment thereof conjugated to an RNA molecule.
A conjugate comprising an anti-TM4SF1 antibody or an antigen binding fragment thereof and an siRNA covalently linked to the anti-TM4SF1 antibody or an antigen binding fragment thereof.
An antibody fragment-RNA conjugate comprising an anti-TM4SF1 Fab′ fragment conjugated to an RNA molecule, wherein the RNA molecule comprises an antisense RNA, an miRNA, an antisense miRNA, an antagomir (anti-miRNA), an shRNA, or an mRNA.
A process for synthesizing an anti-TM4SF1 antibody-siRNA conjugate, comprising:
- conjugating an siRNA with an anti-TM4SF1 or an antigen binding fragment thereof.
A conjugate comprising an anti-TM4SF1 antibody or an antigen binding fragment thereof conjugated to an oligonucleotide.
Dependencies are inferred from the claim text.