Bifunctional molecules for targeting rpn11
AssigneeAmphista Therapeutics Limited
InventorsAlessio CIULLI, Andrea TESTA, Scott HUGHES, Steven Peter BUTCHER
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Abstract
The invention provides for bifunctional molecules comprising an Rpn11 binding partner and a target protein binding partner. A bifunctional molecule according to the invention binds to Rpn11 and to the target protein, thereby facilitating degradation of the target protein bound to the target protein binding partner. The invention also provides for use of a bifunctional molecule for preventing or treating disease.
Claims21
1-47. (canceled)
A bifunctional molecule comprising an Rpn11 binding partner coupled to a target protein binding partner via a covalent linker.
A compound of formula (XI):
- R11L-(CL)-Rx (XI),
- wherein
- refers to a covalent bond;
- R11L is a ligand that binds Rpn11;
- CL is a covalent linker ending in Rx;
- Rx is able to form a covalent chemical bond with a target protein;
- and
- Rx is not PEG.
A pharmaceutical composition, comprising a bifunctional compound according to claim 1, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.