Compositions and methods of fas inhibition
OwnerDavid ZACKS, Andrew KOCAB +5inventors
InventorsDavid ZACKS, Andrew KOCAB, John FRESHLEY, Meredith GREGORY-KSANDER, Anitha KRISHNAN, Jana VAN DE GOOR, Alexander BRIDGES
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Abstract
Described are compositions and methods for preventing, treating or ameliorating an inflammation-mediated and/or complement-mediated disease or condition in a subject comprising administering to the subject a Fas inhibitor, its derivative, a pharmaceutically acceptable salt thereof, of a gene therapy encoding the Fas inhibitor in an amount effective to inhibit Fas signaling.
Claims2
1-20. (canceled)
A method for preventing, treating or ameliorating an inflammation-mediated and/or complement-mediated disease or condition in a subject comprising administering to the subject a Fas inhibitor selected from the group consisting of Met protein, derivatives, fragments, pharmaceutically acceptable salts thereof;
- Met-12, derivatives, fragments, pharmaceutically acceptable salts thereof;
- SEQ ID NOs:
- 1-8, derivatives, fragments, pharmaceutically acceptable salts thereof;
- or a gene therapy agents encoding the Fas inhibitor, in an amount effective to inhibit Fas signaling, and thereby prevent, treat or ameliorate the inflammation-mediated and/or complement-mediated disease or condition in the subject.
Dependencies are inferred from the claim text.