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US 2021/0260133 A1Published application
Cardiac neural crest cells and methods of use thereof
AssigneeVestion, Inc.
InventorsKonstantinos E. CHATZISTERGOS, Joshua M. HARE
Life of this patent
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Abstract
Cardiac neural crest cells and methods for making and using the same to effect cardiac injury is described herein.
Claims26
A method for treating a cardiac injury in a subject in need thereof comprising administering a therapeutically effective amount of a pharmaceutical composition comprising cardiac neural crest cells.
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A method of producing cardiac neural crest cells comprising:
- culturing a plurality of stem cells with noggin and leukemia inhibitory factor;
- culturing the plurality of stem cells with noggin, thereby forming three-dimensional aggregates of the plurality of stem cells;
- and
- culturing the plurality of stem cells in cardiac neural crest differentiation medium to form cardiac neural crest cells.
1 more element
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A pharmaceutical composition comprising cardiac neural crest cells and a pharmaceutically acceptable carrier or excipient.
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Dependencies are inferred from the claim text.