Tunable immune responsive biodegradable arginine-based poly(ester amide)s and methods of making and using same
OwnerChih-Chang CHU, Mingyu HEinventors
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Abstract
The present disclosure provides poly(ester amide)s (PEAs) containing NO-Arg groups. The PEAs may be used to treat diseases having inflammation and/or diseases associated with inflammation. The PEAs may be used to treat wounds, such as, for example, wounds associated with obesity and/or diabetes. The PEAs may be incorporated into various articles such as medical devices, such as, for example, bandages and other wound care articles/devices.
Claims41
A method of treating a subject in need of treatment with one or more poly(ester amide) (PEA) polymer, comprising administering to the subject in need of treatment an effective amount of the one or more PEA polymer(s), wherein the PEA polymer comprises a first pendant group, wherein the first pendant group comprises an alkyl nitroguanidine, and at least a second pendant group chosen from an alkyl guanidine group and a side chain of a canonical amino acid, wherein the alkyl chain of the alkyl nitroguanidine group and alkyl guanidine group is 1 to 6 carbon atoms.
A poly(ester amide) (PEA) polymer, comprising a first pendant group, wherein the first pendant group comprises an alkyl nitroguanidine, and at least a second pendant group chosen from an alkyl guanidine group and a side chain of a canonical amino acid, wherein the alkyl chain of the alkyl nitroguanidine group and alkyl guanidine group is 1 to 6 carbon atoms.
Dependencies are inferred from the claim text.