Composition for treating fibrotic diseases, comprising benzhydryl thioacetamide compound as active ingredient
AssigneeCellion Biomed Inc.
InventorsSuk-Hyo Suh, Seong-Jin Kim
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Abstract
The present invention relates to a composition for treating fibrotic diseases, comprising a benzhydryl thioacetamide compound as an active ingredient, and more specifically to a composition for treating fibrotic diseases, which suppresses the expression of the channel protein KCa2.3 in a cell membrane and has excellent treatment effects particularly on hepatic fibrosis and pulmonary fibrosis.
Claims19
A method for treating a fibrotic disease, the method comprising administering to a subject in need thereof an effective amount of a benzhydryl thioacetamide compound represented by Formula A, or a pharmaceutically acceptable salt thereof, whereby the administration suppresses the expression of a KCa2.3 channel protein in a cell membrane;
- wherein:
- X1˜X10 are each independently hydrogen (H) or fluorine (F), all of which are the same as or different from each other;
- Y is sulfur (S) or sulfoxide (S═O);
- * indicates a chiral position when Y is sulfoxide (S═O);
- and
- R1 is selected from hydrogen, a methyl group, an ethyl group, a methoxy group, an ethoxy group;
- a hydroxyl group, and a carbon compound having 3 to 6 carbon atoms.
(canceled)
Dependencies are inferred from the claim text.