Neostigmine combination and compositions

Abstract

Provided are new methods for treating myasthenia gravis or other myasthenic syndromes comprising use of a therapeutically effective amount of a 5HT3-antagonist in combination with a therapeutically effective amount of a neostigmine compound, that attenuates or even abrogates the dose-limiting gastrointestinal adverse effects of neostigmine. The unique properties of the combination allow for the administration of neostigmine at markedly higher doses, e.g., about 4 times higher than recommended oral doses, and about 100 times higher than recommended parenteral doses, as compared with currently marketed products, without affecting its efficacy in treating symptoms of muscle weakness associated with myasthenia gravis or other myasthenic syndromes.

Dependencies are inferred from the claim text.