Methods of treating schizophrenia and other neuropsychiatric disorders
AssigneesUniversity of Rochester, University of Copenhagen
InventorsSteven A. GOLDMAN, Zhengshan LIU, Mikhail OSIPOVITCH
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Abstract
The present disclosure is directed to methods of restoring glial cell K+ uptake in a subject. This method involves selecting a subject having impaired glial cell K+ uptake, and administering, to the selected subject, a RE1-Silencing Transcription factor (REST) inhibitor under conditions effective to restore glial cell K+ uptake. Subjects having impaired glial cell K+ uptake include those at risk of having or having a neuropsychiatric disease or disorder.
Claims58
A method of restoring K+ uptake in glial cells having impaired K+ uptake, said method comprising
- administering, to the glial cells having impaired K+ uptake, a RE1-Silencing Transcription factor (REST) inhibitor under conditions effective to restore K+ uptake by said glial cells.
A method of restoring glial cell K+ uptake in a subject, said method comprising:
- selecting a subject having impaired glial cell K+ uptake, and
- administering, to the selected subject, a RE1-Silencing Transcription factor (REST) inhibitor under conditions effective to restore glial cell K+ uptake.
A method of treating or inhibiting the onset of a neuropsychiatric disorder in a subject, said method comprising:
- selecting a subject having or at risk of having a neuropsychiatric disorder, and
- administering, to the selected subject, a REST inhibitor under conditions effective to treat or inhibit the onset of the neuropsychiatric disorder in the subject.
Dependencies are inferred from the claim text.