Composition for preventing and treating breast cancer including selenopsammaplin a as active ingredients

A method of preventing or treating cancer selected from the group consisting of breast cancer, liver cancer, and gastric cancer, comprising administering to an individual a pharmaceutical composition comprising an effective amount of selenopsammaplin A or a derivative thereof represented by Formula 1, or a pharmaceutically acceptable salt thereof:

• wherein X is hydrogen, a C1-5 alkyl,
• 1-naphthyl, 2-naphthyl, or 9-anthracenyl,
• R1 to R5 are each independently selected from the group consisting of hydrogen, nitro, a halogen, cyano, hydroxy, dimethylamino, methylsulfonylamide, trifluoromethyl, a C1-5 alkyl, a C1-3 alkoxy, vinyl, aryl, phenoxy, and benzoxy;
• R3 and R4 may be linked to form a ring represented by
• wherein n is an integer of 1, 2 or 3;
• and
• where any of R1 to R5 is phenoxy or benzoxy, the aromatic ring may be substituted with a C1-3 alkyl, a C1-3 alkoxy, a halogen, trifluoromethyl, or t-butyl.

A method of suppressing breast cancer metastasis, comprising administering to an individual a pharmaceutical composition comprising an effective amount of selenopsammaplin A or a derivative thereof represented by Formula 1, or a pharmaceutically acceptable salt thereof:

• wherein X is hydrogen, a C1-5 alkyl,
• 1-naphthyl, 2-naphthyl, or 9-anthracenyl;
• R1 to R5 are each independently selected from the group consisting of hydrogen, nitro, a halogen, cyano, hydroxy, dimethylamino, methylsulfonylamide, trifluoromethyl, a C1-5 alkyl, a C1-3 alkoxy, vinyl, aryl, phenoxy, and benzoxy;
• R3 and R4 may be linked to form a ring represented by
• wherein n is an integer of 1, 2 or 3;
• and
• where any of R1 to R5 is phenoxy or benzoxy, the aromatic ring may be substituted with a C1-3 alkyl, a C1-3 alkoxy, a halogen, trifluoromethyl, or t-butyl.