Platinum complexes and uses thereof
AssigneeL.E.A.F. Holdings Group LLC
InventorsClet NIYIKIZA, Victor M. MOYO
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Abstract
The disclosure generally relates to compositions comprising therapeutic agent complexes and to methods of making and using the compositions. In particular embodiments, the disclosure provides compositions comprising platinum-based drug complexes and to methods of making and using these compositions.
Claims50
A liposome composition comprising a liposome encapsulating (a) a complex of a platinum-based chemotherapeutic agent or a salt thereof and one or more polyglutamates or (b) a complex of a platinum-based chemotherapeutic agent or a salt thereof and a cyclodextrin;
- and one or more pharmaceutically acceptable carriers;
- and a pegylated liposome.
The method of claim 47, wherein the cancer is a member selected from the group:
- lung cancer, pancreatic cancer, breast cancer, ovarian cancer, prostate cancer, head and neck cancer, gastric cancer, gastrointestinal cancer, colorectal cancer, esophageal cancer, cervical cancer, liver cancer, kidney cancer, biliary duct cancer, gallbladder cancer, bladder cancer, sarcoma (e.g., osteosarcoma), brain cancer, central nervous system cancer, and melanoma;
- and a hematologic malignancy such as for example, a leukemia, a lymphoma and other B cell malignancies, myeloma and other plasma cell dyscrasias.
Dependencies are inferred from the claim text.