Ultrasound-induced drug delivery system using drug carrier comprising nanobubbles and drug

Abstract

The present invention relates to an ultrasound-induced drug delivery system using a drug carrier containing a plurality of nanobubbles and a high concentration of a drug in one microcapsule, and specifically is directed to a method for preparing a drug delivery system having a high concentration of a drug and a plurality of nanobubbles encapsulated therein, by generating the nanobubbles in an oil into which the drug is dissolved using a nanobubble generator, and then microencapsulating them; and an ultrasound-induced drug delivery system using the same. The drug delivery system using the nanobubbles according to the present invention is prepared in the form of microcapsules in which both the drug and the nanobubbles are encapsulated, and, in particular, has an effect of maximizing drug delivery efficiency as the nanobubbles collapse or aggregate when the ultrasound is applied to the drug delivery system. Further, since the drug delivery system of the present invention contains a plurality of nanobubbles within the microcapsules, it can also be used as a contrast agent. The drug delivery system prepared according to the method described in this specification and having both the drug and the nanobubbles encapsulated therein has a feature that can simultaneously perform in vivo diagnosis and treatment.

Dependencies are inferred from the claim text.