Cryotherapeutic devices for renal neuromodulation and associated systems and methods

A cryotherapeutic device, comprising:

• an elongated shaft having a distal portion, the distal portion having a terminal end, an inflow orifice, and an exhaust orifice, the inflow and exhaust orifices are proximate to the terminal end, and the shaft is configured to locate the distal portion intravascularly at a treatment site;
• a cooling assembly at the distal portion of the shaft, the cooling assembly including an applicator having an expansion chamber, the distal portion extends axially through the expansion chamber, and the expansion chamber is in fluid communication with the inflow and exhaust orifices;
• a supply lumen configured to transport refrigerant along the shaft to the distal portion, the supply lumen having a distal end connected to the inflow orifice providing a refrigerant path from the supply lumen to the expansion chamber;
• and
• an exhaust passage extending from the exhaust orifice along at least a portion of the shaft, the exhaust passage configured to transport exhausted refrigerant away from the cooling assembly.