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US 2021/0259251 A1Published application
Fungicides to prevent and control fungal pathogens
AssigneeUniversite de Lausanne
InventorsOlga DUBEY, Edward FARMER, Christiane NAWRATH, Katia GINDRO, Sylvain SCHNEE, Sylvain DUBEY
Life of this patent
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Abstract
A field of biological fungicides with a broad range of antifungal activity coming from plant extracts from the order of Brassicales or molecules revealing similar chemical structure. In particular, Applicants surprisingly provided a new usage of a combination of sulfonyl and sulfinyl containing aliphatic glucosinolates, their by-products and synthetic analogues as efficient antifungal compounds with broad spectrum of activity.
Claims14
A method for the prevention or treatment of fungal pathogens in plants comprising treating the plants with a composition comprising the combination of at least two compounds selected from the group consisting of:
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-8-(methylsulfonyl)-octane;
- 1-(isothiocyanatomethyl)-3-(4-(methylsulfinyl)butyl)benzene/1-(isothiocyanatomethyl)-3-(4-(methylsulfonyl)butyl)benzene;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-(ethylsulfonyl)-8-isothiocyanatooctane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-8-(methylsulfinyl)-octane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-9-(methylsulfonyl)-nonane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-9-(methylsulfinyl)-nonane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/8-(methylsulfonyl)octylnitrile or 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-3-(methylsulfonyl)-propane, in the prevention or treatment of fungal pathogens in plants.
19 more elements
The method for the prevention or treatment of mycosis in human or animal patients comprising treating a patient with a composition comprising the combination of at least two compounds selected from the group consisting of:
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-8-(methylsulfonyl)-octane;
- 1-(isothiocyanatomethyl)-3-(4-(methylsulfinyl)butyl)benzene/1-(isothiocyanatomethyl)-3-(4-(methylsulfonyl)butyl)benzene;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-(ethylsulfonyl)-8-isothiocyanatooctane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-8-(methylsulfinyl)-octane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-9-(methylsulfonyl)-nonane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-9-(methylsulfinyl)-nonane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/8-(methylsulfonyl)octylnitrile or 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-3-(methylsulfonyl)-propane, as an antimycotic in food or drink.
19 more elements
A disinfectant composition in oral hygiene or sanitary articles comprising the combination of at least two compounds selected from the group consisting of:
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-8-(methylsulfonyl)-octane;
- 1-(isothiocyanatomethyl)-3 -(4-(methylsulfinyl)butyl)benzene/1-(is othiocyanatomethyl)-3 -(4-(methylsulfonyl)butyl)benzene;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-(ethylsulfonyl)-8-isothiocyanatooctane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2 -ene/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-8-(methylsulfinyl)-octane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-9-(methylsulfonyl)-nonane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-9-(methylsulfinyl)-nonane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/8-(methylsulfonyl)octylnitrile or 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-3-(methylsulfonyl)-propane.
19 more elements
A composition comprising the combination of at least two compounds selected from the group consisting of:
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-8-(methylsulfonyl)-octane;
- 1-(isothiocyanatomethyl)-3-(4-(methylsulfinyl)butyl)benzene/1-(isothiocyanatomethyl)-3-(4-(methylsulfonyl)butyl)benzene;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-(ethylsulfonyl)-8-isothiocyanatooctane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-8-(methylsulfinyl)-octane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-9-(methylsulfonyl)-nonane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-9-(methylsulfinyl)-nonane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/8-(methylsulfonyl)octylnitrile or 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-3-(methylsulfonyl)-propane, for use in a method for preventing or treating mycosis in human or animal patients.
19 more elements
A fungicide composition comprising the combination of at least two compounds selected from the group consisting of:
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-8-(methylsulfonyl)-octane;
- 1-(isothiocyanatomethyl)-3-(4-(methylsulfinyl)butyl)benzene/1-(isothiocyanatomethyl)-3-(4-(methylsulfonyl)butyl)benzene;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-(ethylsulfonyl)-8-isothiocyanatooctane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-8-(methylsulfinyl)-octane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-3-(methylsulfonyl)-propane;
- 1-Isothiocyanato-8-(methylsulfinyl)-octane/1-Isothiocyanato-9-(methylsulfonyl)-nonane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-(ethylsulfinyl)-8-isothiocyanatooctane/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-9-(methylsulfinyl)-nonane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-6-(methylsulfinyl)-hexane;
- (E)-1-isothiocyanato-8-(methylsulfinyl)oct-2-ene/1-Isothiocyanato-7-(methylsulfinyl)-heptane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-3-(methylsulfinyl)-propane;
- 1-Isothiocyanato-8-(methylsulfonyl)-octane/8-(methylsulfonyl)octylnitrile or 1-Isothiocyanato-8-(methylsulfonyl)-octane/1-Isothiocyanato-3-(methylsulfonyl)-propane.
19 more elements
Dependencies are inferred from the claim text.