Immunodeficient mouse
AssigneeCentral Institute for Experimental Animals
InventorsTakeshi Takahashi, Ikumi Katano
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Abstract
An object of the present invention is to provide an immunodeficient mouse which is capable of eliminating effects of immune cells from the immunodeficient mouse against human antibodies and in which human cells are engrafted at high level. Deletion of a mouse FcgR gene from an NOG mouse results in a mouse that does not exhibit antibody-dependent cellular cytotoxic activity on tumors, and in the mouse, human cells can be engrafted at significantly higher level than that in the NOG mouse. Furthermore, by introducing the human IL-15 gene into the mouse and engrafting a human NK cell in the mouse, only human NK cells become effector cells to enable evaluation of ADCC activity.
Claims36
A genetically modified immunodeficient mouse in which a mutation is introduced into the gene of the IL-2 receptor γ chain to disrupt the IL-2 receptor γ chain;
- which has a mutation of a gene involved in rearrangement of antigen receptor genes of T cells and B cells at both allelic loci;
- and in which FcgR is functionally not expressed.
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An immunodeficient mouse engrafted with a human cell (III), which is used for evaluating a function of an antibody against human cell surface protein by allowing a human immune cell and a human tumor cell to co-exist in a genetically modified immunodeficient mouse.
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Dependencies are inferred from the claim text.