US 2021/0254077 A1Published application

Gene targets for improved enzyme production in fungi

AssigneesBattelle Memorial Institute, National Technology & Engineering Solutions of Sandia, LLC

InventorsScott E. Baker, Jon K. Magnuson, Morgann C. Reilly, Joonhoon Kim, John Gladden, Jed J. Lynn

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Abstract

Fungi that are genetically inactivated for the mstC gene (or a homolog thereof) are provided, which can also be genetically modified to increase production of heterologous proteins from a glucoamylase promoter. Methods of using these fungi, for example to degrade a biomass, are also provided.

Claims20

Dependent claims

An isolated fungus comprising a genetic inactivation of a mstC gene or homolog thereof.

Dependencies are inferred from the claim text.

Facts

Application: 17/161,502Filed 28 Jan 2021
Priority: 17 Oct 2017
Published: 19 Aug 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification27 codes

C12N 15/52
DNA or RNA fragments; Modified forms thereof ; Non-coding nucleic acids having a biological activity: genes encoding for enzymes or proenzymes
C07K 14/37
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof: from fungi
C07K 14/38
From fungi: from Aspergillus
C12N 1/145
Fungi ; Culture media therefor: fungi isolates

Family

Application62/573,354Us provisional application · filed 17 Oct 2017
Application16/163,509Division · filed 17 Oct 2018
Application17/161,502Division
US 10,934,551 B2Related patent
US 11,718,854 B2Related patent
US 2019/0112611 A1Published application
US 2021/0254077 A1This patent

From the US filing history. Foreign family members aren’t listed.

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