Kinase inhibitor

A Hippo signal transduction pathway inhibitor comprising a compound represented by the following formula (I) or a salt thereof:

• {wherein, X is a single bond, —CH2COO—, —CONH—, or —NHCO—, R1 is an alkyl group having 1-10 carbon atoms and optionally having substituent(s), an aryl group optionally having substituent(s), or —Y—W—Z—Ar wherein Y and Z are each a single bond or an alkylene group having 1-6 carbon atoms and optionally having substituent(s), W is an oxygen atom, a sulfur atom or N(R4), R4 is a hydrogen atom or an alkyl group having 1-6 carbon atoms, Ar is an aryl group optionally having substituent(s), R2 is an alkyl group having 1-6 carbon atoms and optionally having substituent(s), R3 is a hydroxyl group, and n is 0, 1 or 2}.

A therapeutic agent for a disease or tissue damage associated with failure of cellular proliferation, comprising a compound represented by the following formula (I) or a salt thereof:

• {wherein, X is a single bond, —CH2COO—, —CONH—, or —NHCO—, R1 is an alkyl group having 1-10 carbon atoms and optionally having substituent(s), an aryl group optionally having substituent(s), or —Y—W—Z—Ar wherein Y and Z are each a single bond or an alkylene group having 1-6 carbon atoms and optionally having substituent(s), W is an oxygen atom, a sulfur atom or N(R4), R4 is a hydrogen atom or an alkyl group having 1-6 carbon atoms, Ar is an aryl group optionally having substituent(s), R2 is an alkyl group having 1-6 carbon atoms and optionally having substituent(s), R3 is a hydroxyl group, and n is 0, 1 or 2}.

A proliferation promoter of a cell or tissue for a transplantation treatment, comprising a compound represented by the following formula (I) or a salt thereof:

• {wherein, X is a single bond, —CH2COO—, —CONH—, or —NHCO—, R1 is an alkyl group having 1-10 carbon atoms and optionally having substituent(s), an aryl group optionally having substituent(s), or —Y—W—Z—Ar wherein Y and Z are each a single bond or an alkylene group having 1-6 carbon atoms and optionally having substituent(s), W is an oxygen atom, a sulfur atom or N(R4), R4 is a hydrogen atom or an alkyl group having 1-6 carbon atoms, Ar is an aryl group optionally having substituent(s), R2 is an alkyl group having 1-6 carbon atoms and optionally having substituent(s), R3 is a hydroxyl group, and n is 0, 1 or 2}.

An optically active form of a compound represented by the following formula (I), or a salt thereof:

• {wherein, X is a single bond, —CH2COO—, —CONH—, or —NHCO—, R1 is an alkyl group having 1-10 carbon atoms and optionally having substituent(s), an aryl group optionally having substituent(s), or —Y—W—Z—Ar wherein Y and Z are each a single bond or an alkylene group having 1-6 carbon atoms and optionally having substituent(s), W is an oxygen atom, a sulfur atom or N(R4), R4 is a hydrogen atom or an alkyl group having 1-6 carbon atoms, Ar is an aryl group optionally having substituent(s), R2 is an alkyl group having 1-6 carbon atoms and optionally having substituent(s), R3 is a hydroxyl group, and n is 0, 1 or 2 (provided that when X is —NHCO—, R2 is an ethyl group, and n is 0, then R1 is not —CH2—NH—C6H5)}.