High thebaine poppy and methods of producing the same
AssigneeApi Labs Inc.
InventorIgor KOVALCHUK
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Abstract
This disclosure relates to the production of opium poppy plants having high levels of thebaine. More particularly, the disclosure relates to the production of opium poppies having high levels of thebaine by simultaneously reducing the expression of genes encoding thebaine 6-0-demethylase (T60DM) and codeine 3-0-demethylase (CODM).
Claims31
A method of increasing accumulation of thebaine in an opium poppy plant, the method comprising genetically modifying the genome of the plant to include one or more stable genetic modifications to simultaneously reduce the activity of thebaine 6-O-demethylase (T6ODM) and codeine 3-O-demethylase (CODM) in the poppy plant.
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A genetically modified opium poppy plant having reduced activity of thebaine 6-O-demethylase (T6ODM) and-codeine 3-O-demethylase (CODM) relative to a wild type plant, wherein the genetically modified opium poppy plant comprises one or more stable genetic modifications to reduce expression of T6ODM, CODM, or both.
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An isolated nucleic acid molecule, wherein the sequence of the nucleic acid molecule comprises SEQ ID NO:7.
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Dependencies are inferred from the claim text.