Use of the u94 molecule of human herpesvirus 6 and derivatives thereof to increase or induce the expression of the hla-g molecule
OwnerArnaldo CARUSO, Roberta RIZZO +3inventors
InventorsArnaldo CARUSO, Roberta RIZZO, Dario DI LUCA, Elisabetta CASELLI, Francesca CACCURI
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Abstract
A method of enhancing or inducing the expression of the HLA-G molecule by human cells is provided. The method includes administering the human Herpesvirus 6 U94 molecule or a derivative thereof, or a gene expression vector including and expressing the human Herpesvirus 6 U94 gene to a patient in need thereof or to an in vitro cell, tissue, or organ culture.
Claims12
1-10. (canceled)
A method of administering an immuno-suppression and/or anti-inflammatory treatment to a subject in need thereof, the method comprising administering to the subject an amount of human Herpesvirus 6 U94 molecule or derivative thereof, the amount being effective in enhancing or inducing HLA-G expression in cells and/or tissues of the subject.
A method of administering an immuno-suppression and/or anti-inflammatory treatment to a subject in need thereof, the method comprising administering to the subject an amount of a gene expression vector including and expressing the human Herpesvirus 6 U94 gene, the amount being effective in enhancing or inducing HLA-G expression in cells and/or tissues of the subject.
An in vitro method for modulating the expression of the HLA-G molecule in a mammalian cell, tissue, or organ culture, the in vitro method comprising administering to said culture the human Herpesvirus 6 U94 molecule or a derivative thereof.
An in vitro method for modulating the expression of the HLA-G molecule in a mammalian cell, tissue, or organ culture, the in vitro method comprising administering to said culture a gene expression vector including and expressing the human Herpesvirus 6 U94 gene.
Dependencies are inferred from the claim text.