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US 2021/0244764 A1Published application
Novel cellular receptors and uses thereof
AssigneeTrustees of Boston University
InventorsJohn T. NGO, Jeffrey Blye MCMAHAN
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Abstract
Described herein are polypeptides, systems, and methods that relate to using domains that bind specifically to a biotinylamide to control receptor and cellular activity.
Claims23
A synthetic signaling system comprising:
- a) a first small molecule-controlled signaling polypeptide comprising i) a small molecule acceptor peptide or a small molecule and ii) at least a first signaling domain;
- and a second small molecule-controlled signaling polypeptide comprising i) a domain that binds specifically to a small molecule and ii) at least a second signaling domain;
- b) a first small molecule-controlled signaling polypeptide comprising i) a small molecule acceptor peptide or a small molecule and ii) at least a first signaling domain;
- and a polypeptide comprising a domain that binds specifically to the small molecule;
- or
- c) a second small molecule-controlled signaling polypeptide comprising i) a domain that binds specifically to a small molecule and ii) at least a second signaling domain and a polypeptide comprising a small molecule acceptor peptide or a small molecule.
3 more elements
Dependencies are inferred from the claim text.