Compositions and methods for suppressing or reducing systemic immune response in a subject
AssigneeThe Trustees of the University of Pennsylvania
InventorTaku KAMBAYASHI
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Abstract
The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.
Claims8
1-46. (canceled)
A method of suppressing or reducing systemic immune response in a subject in need thereof,
- the method comprising administering to the subject a pharmaceutically effective amount of a polypeptide comprising a TSLP isoform,
- wherein the isoform has at least 85% identity with at least one selected from the group consisting of SEQ ID NO:1 and SEQ ID NO:2.
A method of treating a systemic inflammatory disease or disorder in a subject in need thereof,
- the method comprising administering to the subject a pharmaceutically effective amount of a polypeptide comprising a TSLP isoform,
- wherein the isoform has at least 85% identity with at least one selected from the group consisting of SEQ ID NO:1 and SEQ ID NO:2,
- wherein the disease or disorder is selected from the group consisting of type I diabetes, type II diabetes, atherosclerosis, multiple sclerosis, and rheumatoid arthritis.
A kit for suppressing or reducing systemic immune response in a subject, the kit comprising at least one agent selected from a vitamin D3 analog and a polypeptide comprising a TSLP isoform, and instructions for administering the agent to the subject, wherein the analog is to be administered topically to the subject.
Dependencies are inferred from the claim text.