# US 2021/0244022 A1 · Colloidal particle formulations with advanced functionality > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2021/0244022 A1 - Document ID: US20210244022A1 - Status: Published application - Kind: A1 - Application number: 17/247,808 - Filed: 2020-12-23 - Published: 2021-08-12 - Earliest claimed: 2020-02-12 - Assignees: Benanova Inc. - Applicants: Benanova Inc. - Inventors: Anka Veleva - Web page: https://patentgrep.com/patent/US20210244022A1 ## CPC - A01N 25/22: containing ingredients stabilising the active ingredients - A01N 25/04: Dispersions, {emulsions, suspoemulsions, suspension concentrates} or gels (foams A01N25/16) - A01N 25/10: Macromolecular compounds - A01N 59/20: Copper - A01P 1/00: Disinfectants; Antimicrobial compounds or mixtures thereof - C07G 1/00: Low-molecular-weight derivatives of lignin (high-molecular-weight derivatives of lignin {C08H6/00}) - C08L 97/00: Compositions of lignin-containing materials (of polysaccharides C08L1/00 - C08L5/00) - C08L 97/005: {Lignin} - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - A01P: BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS - C07G: COMPOUNDS OF UNKNOWN CONSTITUTION (sulfonated fats, oils or waxes of undetermined constitution C07C309/62) - C08L: COMPOSITIONS OF MACROMOLECULAR COMPOUNDS (compositions based on polymerisable monomers C08F, C08G; artificial filaments or fibres D01F; textile treating compositions D06) ## Abstract Disclosed is a method for creating a composite colloidal particle formulation with advanced functionality that possesses highly efficient and effective properties. The composite colloidal particle formulation comprises an engineered biodegradable particle core dispersed in a bioadhesive polyelectrolyte solution. Also disclosed are methods of use of the same, including but not limited to applying said formulation to plants for disease treatment. ## Claims ### Claim 1 A method of creating a composite colloidal particle formulation comprising an engineered biodegradable particle core, the method comprising: a. Contacting an ethanol-based solvent containing dissolved biopolymer with an anti-solvent in a T-piece so as to form an engineered biodegradable particle core; and b. Dispersing the engineered biodegradable particle core in a bioadhesive polyelectrolyte solution. ### Claim 2 (depends on 1) The composite colloidal particle formulation produced by the method of claim 1. ### Claim 3 (depends on 2) The composite colloidal particle formulation of claim 2, wherein the engineered biodegradable particle core comprises a plant-derived biopolymer. ### Claim 4 (depends on 2) The composite colloidal particle formulation of claim 2, wherein the engineered biodegradable particle core comprises a lignin, a modified lignin, polysaccharide, modified polysaccharide or a combination thereof. ### Claim 5 (depends on 4) The composite colloidal particle formulation of claim 4, wherein the modified lignin is an unsulfonated or sulfonated lignin. ### Claim 6 (depends on 4) The composite colloidal particle formulation of claim 4, wherein the polysaccharide is cellulose, hemicellulose, lignocellulose, glyco-protein, or a combination thereof. ### Claim 7 (depends on 4) The composite colloidal particle formulation of claim 4, wherein the composite colloidal particle formulation comprises lignin at a concentration of at least 0.001 percent by weight. ### Claim 8 (depends on 2) The composite colloidal particle formulation of claim 2, wherein the composite colloidal particle formulation is cationic. ### Claim 9 (depends on 2) The composite colloidal particle formulation of claim 2, wherein the composite colloidal particle formulation comprises carbohydrates, polypeptides, lectins, proteins, or antibodies or other molecules or materials with affinity to microbes, viruses, seeds, or plant foliage. ### Claim 10 (depends on 2) The composite colloidal particle formulation of claim 2, wherein the composite colloidal particle formulation comprises chitosan at a concentration of at least 0.005 percent by weight. ### Claim 11 (depends on 2) The composite colloidal particle formulation of claim 2, wherein the particle has a diameter of about 10 nm to about 500 nm. ### Claim 12 (depends on 2) A coated article comprising a surface wherein at least a portion of the surface is coated with the composite colloidal particle system of claim 2. ### Claim 13 (depends on 2) A method for treating or preventing disease in a plant comprising applying to the plant the composite colloidal particle formulation of claim 2. ### Claim 14 (depends on 13) The method of treating or preventing disease in claim 13 wherein the disease is caused by a bacterial or fungal pathogen. ### Claim 15 (depends on 13) The method of claim 13 wherein the disease is bacterial spot. ### Claim 16 A method of producing final formulation volumes of at least one liter, of a composite colloidal particle formulation comprising an engineered biodegradable particle core, the method comprising: a. Contacting an ethanol-based solvent containing dissolved biopolymer with an anti-solvent in a T-piece so as to form an engineered biopolymer particle core; and b. Dispersing the engineered biodegradable particle core in a bioadhesive polyelectrolyte solution. ### Claim 17 (depends on 13) The method of claim 13, wherein the plant is a member of the family Solanaceae. ### Claim 18 (depends on 13) The method of claim 13, wherein the plant is a member of the genus Capsicum. ### Claim 19 (depends on 13) The method of claim 13, wherein the plant is a member of the genus Lycopersicon.