# US 2021/0241046 A1 · Compositions and methods for cancer detection and classification using neural networks

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- Number: US 2021/0241046 A1
- Document ID: US20210241046A1
- Status: Published application
- Kind: A1
- Application number: 17/105,204
- Filed: 2020-11-25
- Published: 2021-08-05
- Earliest claimed: 2019-11-26
- Assignees: University of North Texas
- Applicants: University of North Texas
- Inventors: Rajeev AZAD; Steven GORE
- Web page: https://patentgrep.com/patent/US20210241046A1

## CPC

- G06N 3/088: Non-supervised learning, e.g. competitive learning
- G06F 18/2411: based on the proximity to a decision surface, e.g. support vector machines
- G06N 3/045: Combinations of networks
- G06N 3/0455: Auto-encoder networks; Encoder-decoder networks
- G06N 3/047: Probabilistic or stochastic networks
- G06N 3/0475: Generative networks
- G06N 3/09: Supervised learning
- G06V 20/69: Microscopic objects, e.g. biological cells or cellular parts
- G06N 3/105: {Shells for specifying net layout}
- G06N 20/10: using kernel methods, e.g. support vector machines [SVM]
- G06N: COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
- G06F: ELECTRIC DIGITAL DATA PROCESSING (computer systems based on specific computational models G06N)
- G06V: IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING

## Abstract

In alternative embodiments, provided are computer-implemented methods using neural networks for detecting and classifying cancers. Also provided are methods for diagnosing a cancer comprising use of a computer-implemented method for detecting and classifying cancers as provided herein. Also provided are methods for treating a cancer comprising use of a computer-implemented method for detecting and classifying cancers as provided herein.

## Claims

### Claim 1

A computer-implemented method for detecting and classifying cancers comprising: a computer-implemented method comprising a sub set of, substantially all, or all of the steps as set forth in the flow chart of FIG. 10.

### Claim 2 (depends on 1)

A computer program product for processing data, the computer program product comprising: computer-executable logic contained on a computer-readable medium (optionally a non-transitory computer-readable medium) and configured for causing the following computer-executed steps to occur: executing the computer-implemented method of claim 1.

### Claim 3 (depends on 1, 2)

A Graphical User Interface (GUI) computer program product comprising: program instructions for running, processing and/or implementing: (a) a computer-implemented method of claim 1; (b) a computer program product of claim 2.

### Claim 4 (depends on 1, 2, 3)

A computer system comprising a processor and a data storage device wherein said data storage device has stored thereon: (a) a computer-implemented method of claim 1; (b) a computer program product of claim 2; (c) a Graphical User Interface (GUI) computer program product of claim 3; or, (d) a combination thereof.

### Claim 5 (depends on 1, 2, 3, 4)

A non-transitory memory medium, or a comprising program instructions for running, processing and/or implementing: (a) a computer-implemented method of claim 1; (b) a computer program product of claim 2; (c) a Graphical User Interface (GUI) computer program product of claim 3; (d) a computer system of claim 4; or (e) a combination thereof.

### Claim 6 (depends on 1, 2, 3, 4)

A non-transitory computer readable medium storing an executable program comprising instructions to perform a method claim 1; (b) a computer program product of claim 2; (c) a Graphical User Interface (GUI) computer program product of claim 3; (d) a computer system of claim 4; or (e) a combination thereof.

### Claim 7 (depends on 1)

A method for diagnosing a cancer comprising use of a computer-implemented method for detecting and classifying cancers as set forth in claim 1.

### Claim 8 (depends on 6)

The method of claim 6, wherein the cancer is Adrenocortical carcinoma (ACC), Bladder Urothelial Carcinoma (BLCA), Breast invasive carcinoma (BRCA), Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), Cholangiocarcinoma (CHOL), Colon adenocarcinoma (COAD), Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (DLBC), Esophageal carcinoma (ESCA), Glioblastoma multiforme (GBM), Head and Neck squamous cell carcinoma (HNSC), Kidney Chromophobe (KICH), Kidney renal clear cell carcinoma (KIRC), Kidney renal papillary cell carcinoma (KIRP), Acute Myeloid Leukemia (LAML), Chronic Myelogenous Leukemia (LCML), Brain Lower Grade Glioma (LGG), Liver hepatocellular carcinoma (LIHC), Lung adenocarcinoma (LUAD), Lung squamous cell carcinoma (LUSC), Mesothelioma (MESO), Ovarian serous cystadenocarcinoma (OV), Pancreatic adenocarcinoma (PAAD), Pheochromocytoma and Paraganglioma (PCPG), Prostate adenocarcinoma (PRAD), Rectum adenocarcinoma (READ), Sarcoma (SARC), Skin Cutaneous Melanoma (SKCM), Stomach adenocarcinoma (STAD), Testicular Germ Cell Tumors (TGCT), Thyroid carcinoma (THCA), Thymoma (THYM), Uterine Corpus Endometrial Carcinoma (UCEC), Uterine Carcinosarcoma (UCS), or Uveal Melanoma (UVM).

### Claim 9 (depends on 1)

A method for treating a cancer comprising use of a computer-implemented method for detecting and classifying cancers as set forth in claim 1, wherein the method comprises: (a) using the computer-implemented method for detecting and classifying a cancer in an individual in need thereof, and (b) treating the detected and classified cancer.

### Claim 10 (depends on 8)

The method of claim 8, wherein the cancer is Adrenocortical carcinoma (ACC), Bladder Urothelial Carcinoma (BLCA), Breast invasive carcinoma (BRCA), Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), Cholangiocarcinoma (CHOL), Colon adenocarcinoma (COAD), Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (DLBC), Esophageal carcinoma (ESCA), Glioblastoma multiforme (GBM), Head and Neck squamous cell carcinoma (HNSC), Kidney Chromophobe (KICH), Kidney renal clear cell carcinoma (KIRC), Kidney renal papillary cell carcinoma (KIRP), Acute Myeloid Leukemia (LAML), Chronic Myelogenous Leukemia (LCML), Brain Lower Grade Glioma (LGG), Liver hepatocellular carcinoma (LIHC), Lung adenocarcinoma (LUAD), Lung squamous cell carcinoma (LUSC), Mesothelioma (MESO), Ovarian serous cystadenocarcinoma (OV), Pancreatic adenocarcinoma (PAAD), Pheochromocytoma and Paraganglioma (PCPG), Prostate adenocarcinoma (PRAD), Rectum adenocarcinoma (READ), Sarcoma (SARC), Skin Cutaneous Melanoma (SKCM), Stomach adenocarcinoma (STAD), Testicular Germ Cell Tumors (TGCT), Thyroid carcinoma (THCA), Thymoma (THYM), Uterine Corpus Endometrial Carcinoma (UCEC), Uterine Carcinosarcoma (UCS), or Uveal Melanoma (UVM).