Biological material detection sensor and the fabricating method thereof
AssigneeKorea University Research and Business Foundation, Sejong Campus
InventorsJin Sung PARK, Seong Jae JO, Joo Hyung PARK, Won Seok LEE, Heon Jeong LEE, Dae Sung YOON, Gyu Do LEE, In Su KIM
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Abstract
Provided is a biomaterial detection sensor. The biomaterial detection sensor comprises a substrate and a detection probe including a metal nanoparticle deposited on the substrate, and an erythrocyte membrane conformally covering the metal nanoparticle, wherein the detection probe may selectively react with fibrinogen.
Claims20
A biomaterial detection sensor comprising:
- a substrate;
- and
- a detection probe including a metal nanoparticle deposited on the substrate, and an erythrocyte membrane conformally covering the metal nanoparticle,
- wherein the detection probe sensitively reacts with fibrinogen.
A method for fabricating a biomaterial detection sensor, comprising:
- preparing a substrate and a metal nanoparticle;
- depositing the metal nanoparticle on the substrate;
- extracting an erythrocyte membrane from an erythrocyte;
- and
- providing the erythrocyte membrane on the substrate where the metal nanoparticle is deposited, so as to form a detection probe including the metal nanoparticle on the substrate and the erythrocyte membrane conformally covering the metal nanoparticle.
A method for fabricating a biomaterial detection sensor, comprising:
- extracting an erythrocyte from blood;
- crushing the extracted erythrocyte;
- separating an erythrocyte membrane from the crushed erythrocyte;
- and
- providing the erythrocyte membrane on an electrode, so as to form an erythrocyte membrane coating layer having a fibrinogen receptor.
A biomaterial detection sensor comprising:
- an electrode;
- and
- an erythrocyte membrane coating layer formed on the electrode and made of an erythrocyte membrane having a fibrinogen receptor,
- wherein the biomaterial detection sensor provides a charge transfer resistance value that varies depending on a reaction of fibrinogen to the fibrinogen receptor.
The biomaterial detection sensor comprising:
- a substrate;
- and
- a detection probe including a metal nanoparticle deposited on the substrate, and an aptamer linked to the metal nanoparticle,
- wherein the detection probe selectively reacts with cortisol.
A method for fabricating a biomaterial detection sensor, comprising:
- preparing a substrate;
- preparing a metal nanoparticle having a size controlled;
- depositing the metal nanoparticle on the substrate;
- and
- providing an aptamer on the substrate where the metal nanoparticle is deposited, so as to form a detection probe in which the metal nanoparticle on the substrate is linked to the aptamer.
Dependencies are inferred from the claim text.