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AssigneeCodexis, Inc.
InventorsJoyce Liu, Leann Quertinmont Teadt, Nikki Dellas, Stephan Jenne, Faye Loan Du, Kristen Jean Vallieu, Kerryn McCluskie
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The present invention provides engineered leucine decarboxylase (LDC) polypeptides and compositions thereof, as well as polynucleotides encoding the engineered leucine decarboxylase (LDC) polypeptides. In some embodiments, the engineered LDC polypeptides are optimized to provide enhanced catalytic activity, as well as reduced sensitivity to proteolysis, and/or increased tolerance to low pH environments. In some embodiments, the engineered LDC polypeptides are optimized to provide improved storage stability. The present invention also provides methods for the use of the compositions comprising the engineered LDC polypeptides for therapeutic and industrial purposes.
An engineered leucine decarboxylase polypeptide comprising an amino acid sequence having at least 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92,%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or more sequence identity to at least one of SEQ ID NO:
An engineered leucine decarboxylase polypeptide comprising an amino acid sequence having at least 90% sequence identity to SEQ ID NO:
Dependencies are inferred from the claim text.