Uses and methods for oncolytic virus targeting of il-4/il-13 and fusions thereof
AssigneeMedicenna Therapeutics Inc.
InventorFahar Merchant
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Abstract
The present invention provides an oncolytic virus vector containing a sequence encoding IL-4 receptor targeted cargo protein, including IL-4 muteins and/or IL-13 muteins, the oncolytic virus encoded therefrom, the uses of the oncolytic virus for treating cancer.
Claims68
A modified oncolytic virus vector comprising at least one nucleic acid sequence encoding an IL-4 receptor targeted cargo protein, wherein the oncolytic virus is selected from the group consisting of an adenovirus, a self-replicating alphavirus, a vaccinia virus, a Seneca Valley Virus, a Newcastle disease Virus, a maraba virus, vesicular stomatitis virus (VSV), a Herpes virus (including HSV-1 and HSV-2), a measles virus, a poliovirus, a reovirus, a coxsackie virus, a lentivirus, a morbillivirus, an influenza virus, Sinbis virus, myxoma virus, and a retrovirus.
A modified oncolytic vaccinia virus vector comprising a modified vaccinia virus genome and at least one nucleic acid sequence encoding an IL-4 receptor targeted cargo protein, wherein the modified oncolytic vaccinia virus vector encodes a modified oncolytic vaccinia virus characterized by inactivation or partial inactivation of thymidine kinase (TK) and vaccinia growth factor.
A modified oncolytic adenovirus vector comprising (i) an adenovirus genome, wherein optionally the nucleotides encoding amino acids 122-129 of ElA polypeptide are deleted, and (ii) at least one nucleic acid sequence encoding an IL-4 receptor targeted cargo protein.
A modified oncolytic rhabdovirus vecto sequence encoding an IL-4 receptor targeted cargo protein.
The modified oncolytic vector or virus o sequence including any one of SEQ ID NOs:2-48.
The modified oncolytic vector or virus o amino acid substitutions L80F, R81D, L85V, I86V, and I92F in comparison to wild-type human IL-2 of SEQ ID NO:81.
Dependencies are inferred from the claim text.