Compositions and methods for treating eye infections and disease
AssigneeUniversity of Virginia Patent Foundation
InventorGordon W. Laurie
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Abstract
The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a bioactive fragment thereof. The application discloses in part that a ˜90 KDa deglycanated form of syndecan-1 is abundant in tears of normal individuals but not individuals suffering from dry eye, whereas a ˜25 kDa syndecan-1 fragment is detectable in dry, but not normal tears.
Claims10
1-20. (canceled)
A method comprising determining the concentration of monomeric lacritin in the tear sample from an individual and determining if a decreased concentration of monomeric lacritin is present in the sample relative to a predetermined standard for monomeric lacritin.
The method of 21, wherein determining the concentration monomeric lacritin in the tear sample comprises a method selected from the group comprising an enzyme-linked immunosorbent assay (ELISA), immunoassay, immunofluorescence, immunohistochemistry, immunoprecipitation, and western blot.
Dependencies are inferred from the claim text.