Compositions and methods for treating vascular disease in selected patients
AssigneeThe University of Vermont and State Agriculture College
InventorDavid Schneider
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Abstract
As described below, the present invention features methods for treating selected subjects at increased risk of a cardiovascular event, wherein the subjects are selected as having elevated platelet Fcγgamma RIIa.
Claims22
A method of treating a selected subject at increased risk of a cardiovascular event, the method comprising administering to the subject an anti-inflammatory agent, wherein the subject is selected by detecting an increased level of FcγRIIa on platelets from the subject relative to a reference.
A method of treating a selected subject having systemic inflammation, the method comprising administering to the subject an anti-inflammatory agent, wherein the subject is selected by detecting an increased level of FcγRIIa on platelets from the subject relative to a reference.
A method of identifying a subject at increased risk of a cardiovascular event comprising:
- determining a level of FcγRIIa on platelets from the subject;
- and
- comparing the level of FcγRIIa on the platelets with a reference value, wherein an increased level compared to the reference value indicates that the subject is at increased risk of a cardiovascular event.
A method of identifying a subject as having systemic inflammation comprising:
- determining a level of FcγRIIa on platelets from the subject;
- and
- comparing the level of FcγRIIa on the platelets with a reference value wherein an increased level compared to the reference value indicates that the subject has systemic inflammation.
16-17. (canceled)
The method of claim 17, wherein the increased level of platelet FcγRIIa expression is greater than about 11,000 copies of FcγRIIa per platelet.
19-20. (canceled)
Dependencies are inferred from the claim text.