Magnesium ion selective membranes
AssigneeRadiometer Medical ApS
InventorsThomas Pedersen NYGAARD, Palle SCHNEIDER, Peter Jakobsen NEILSON, Thomas Steen HANSEN, Thomas LAURSEN
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Abstract
Magnesium ion selective electrode membranes and the preparation thereof. The membranes are rendered highly selective for magnesium ions by the addition of acidic groups to the preferably PVC membrane, either by introducing a lipophilic compound comprising an acidic group covalently linked to a C4-C18 alkyl-substituted phenyl group (e.g. bis-4-octylphenyl phosphoric acid) into the membrane comprising the magnesium selective ionophore (e.g. a neutral ionophore 1,10-phenanthroline derivative) or by covalently linking an acidic (e.g. a carboxylic) group to the ionophore (e.g. a 1,10- phenanthroline derivative).
Claims23
A magnesium ion selective membrane comprising:
- a. an ionophore;
- and
- b. a lipophilic compound comprising an acidic group, wherein the lipophilic compound is a compound of the formula I:
- wherein A comprises an acidic group,
- wherein one, two or all three of R18, R19 and R20 is a C4-18 group, which is a C4-18alkyl group, a C4-18alkenyl group, a C4-18alkynyl group, or an amide-containing C4-18 group, wherein said C4-18 group is linear at positions 1, 2 and 3, counting from the phenyl group, or in total only has one side chain at said positions 1, 2 and 3,
- and wherein any remaining of R18, R19 and R20 independently are hydrogen, or a linear C1-18 alkyl,
- or a salt of said lipophilic compound.
A magnesium ion selective membrane comprising:
- i) an ionophore covalently linked to an acidic group via a spacer wherein said spacer comprises at least one carbon atom or
- ii) a salt of said ionophore covalently linked to an acidic group.
Dependencies are inferred from the claim text.