Nozzle plate for fiber formation

A method, comprising:

• contacting a first surface of a scaffold with at least one source of a polymeric material, the scaffold comprising a second surface opposite the first surface and plurality of pores extending through the first and second surfaces, wherein each pore comprises a first channel, and a first conjunction interface configured to couple with a second conjunction interface of a removable nozzle or a third conjunction interface of a removable closure structure;
• coupling the first conjunction interfaces of a portion of the pores to the second conjunction interfaces of a plurality of removable nozzles, wherein each removable nozzle comprises a second channel in fluidic communication with the first channel of the pore to which it is coupled, wherein at least each of the second channels have an internal diameter configured to allow formation of a fiber from the polymeric material;
• coupling the first conjunction interfaces of any remaining pores with the third conjunction interfaces of a plurality of removable closure structures, wherein each removable closure structure is configured to seal the pore to which it is coupled;
• and
• extruding the polymeric material from the second channels of the removable nozzles to form the fibers.

A bi-channel electrospinning nozzle, comprising a core unit and a shell unit, wherein:

• the core unit comprises:
• a core channel cover enclosing a core channel, wherein the core channel cover has a proximal end and the distal end;
• a spacer surrounding a distal portion of the core channel cover;
• and
• a first shell channel cover surrounding a proximate portion of the core channel cover, wherein an internal surface of the first shell channel cover and an external surface of the core channel cover form a shell channel, and wherein a distal portion of the first shell channel cover comprises one or more openings connecting the first shell channel and the external space;
• and
• the shell unit comprises a second shell channel cover comprising a proximal end and a distal portion that is configured to be removably attached to the proximal portion of the first shell channel cover while allowing the proximal end of the core channel cover to go through an internal shell channel of the shell unit.