Multi-color fish test for bladder cancer detection
AssigneeBoard of Regents, The University of Texas System
InventorsBogdan CZERNIAK, Keith BAGGERLY, Jolanta BONDARUK, Tadeusz MAJEWSKI, Colin DINNEY, Shizhen ZHANG, Yan WANG
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Abstract
The present disclosure provides methods and compositions for the detection of bladder in a subject using four locus-specific probes to 6p22, 8q22, 11q13, and 20p11.2.
Claims23
An in vitro method of detecting the presence of four probes comprising:
- (a) obtaining a set of locus-specific probes for 6p22, 8q22, 11q13, and 20p11.2;
- (b) hybridizing the set of locus-specific probes to a plurality of nucleic acids;
- and
- (c) analyzing the hybridization pattern of the set of locus-specific probes to the plurality of nucleic acids, thereby detecting the presence of the four probes.
2-25. (canceled)
A method of treating cancer in a subject comprising administering one or more anti-cancer therapies to the subject, wherein the subject is identified to have an abnormal copy number at the loci 6p22, 8q22, 11g13, and 20p11.2.
33-35. (canceled)
A kit for detecting cancer comprising a set of locus-specific probes to 6p22, 8q22, 11q13, and 20p11.2.
37-39. (canceled)
Dependencies are inferred from the claim text.