Genetic regulation of immunoresponse by chromosome interactions

A process for detecting a chromosome state which represents a subgroup in a population comprising determining whether a chromosome interaction relating to that chromosome state is present or absent within a defined region of the genome, wherein said subgroup relates to how immunoresponsive individuals are;

• and
• wherein said chromosome interaction has optionally been identified by a method of determining which chromosomal interactions are relevant to a chromosome state corresponding to an immunoresponsive subgroup of the population, comprising contacting a first set of nucleic acids from subgroups with different states of the chromosome with a second set of index nucleic acids, and allowing complementary sequences to hybridise, wherein the nucleic acids in the first and second sets of nucleic acids represent a ligated product comprising sequences from both the chromosome regions that have come together in chromosomal interactions, and wherein the pattern of hybridisation between the first and second set of nucleic acids allows a determination of which chromosomal interactions are specific to an immunoresponsive subgroup;
• and
• wherein the chromosome interaction either:
• (i) is present in any one of the regions or genes listed in Table 1;
• and/or
• (ii) corresponds to any one of the chromosome interactions represented by any probe shown in Table 1, and/or
• (iii) is present in a 4,000 base region which comprises or which flanks (i) or (ii);
• or
• a) is present in any one of the regions or genes listed in Table 13;
• and/or
• b) corresponds to any one of the chromosome interactions represented by any probe shown in Table 13, and/or
• c) is present in a 4,000 base region which comprises or which flanks (a) or (b);
• or
• (α) is present in any one of the regions or genes listed in Table 16;
• and/or
• (β) corresponds to any one of the chromosome interactions represented by any probe shown in Table 16, and/or
• (γ) is present in a 4,000 base region which comprises or which flanks (α) or (β).