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US 2021/0230690 A1Published application
Biosensor
OwnerJeroen Lammertyn, Saba Safdar +1inventors
InventorsJeroen Lammertyn, Saba Safdar, Dragana Spasic
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Abstract
Present invention in general concerns (re-)engineering the CRISPR/CAS guide RNA for protein independent signal generation.
Claims26
(canceled)
A biosensor comprising a transducer element associated with an engineered CRISPR system comprising a guide RNA-NAzyme hybrid.
14-16. (canceled)
A sensor kit comprising:
- a hybrid tracrRNA-NAzyme in a complex with Cas-crRNA;
- or
- a hybrid tracrRNA-NAzyme in a complex with Cas9-crRNA;
- or
- a hybrid tracrRNA-NAzyme in a complex with dCas-crRNA;
- or
- a hybrid tracrRNA-NAzyme in a complex with dCas-crRNA and further including a substrate for NAzyme.
4 more elements
18-19. (canceled)
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27-30. (canceled)
32-33. (canceled)
Dependencies are inferred from the claim text.