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US 2021/0230679 A1Published application
Methods of epigenetic analysis
AssigneesChildren's Medical Center Corporation, The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsAnjana Rao, Mamta Tahiliani, Kian Peng Koh, Suneet Agarwal, Aravind Iyer
Life of this patent
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Abstract
The present invention provides for methods of epigenetic analysis. In some cases, the methods may include obtaining a sample comprising a nucleic acid sequence. In some cases, the nucleic acid sequence may comprise one or more epigenetic marks. The methods may include performing a sequencing. The methods may include distinguishing a hydroxymethylated base from a methylated base.
Claims22
-10. (canceled)
A method, comprising:
- contacting a polynucleotide with an enzyme or a catalytically active fragment thereof that performs an oxidation on an epigenetic modification to form a contacted polynucleotide;
- and
- sequencing the contacted polynucleotide.
Dependencies are inferred from the claim text.