Method for selecting polynucleotides based on enzyme interaction duration
AssigneeOxford Nanopore Technologies PLC
InventorsAndrew John Heron, Rebecca Victoria Bowen
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Abstract
A method for selecting polynucleotides, the method comprising: allowing a nucleic acid handling enzyme to move along multiple polynucleotides in a sample for a defined time period, wherein the enzyme is loaded onto each of the multiple polynucleotides and wherein one or more molecule of the enzyme moves along each of the multiple polynucleotides; and selecting polynucleotides based on whether or not the enzyme reaches the end of and/or unbinds from the polynucleotides in the defined time period.
Claims33
A method for selecting polynucleotides, the method comprising:
- (i) allowing a nucleic acid handling enzyme to move along multiple polynucleotides in a sample for a defined time period, wherein the enzyme is loaded onto each of the multiple polynucleotides and wherein one or more molecule of the enzyme moves along each of the multiple polynucleotides;
- and
- (ii) selecting polynucleotides based on whether or not the enzyme reaches the end of and/or unbinds from the polynucleotides in the defined time period.
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Dependencies are inferred from the claim text.