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US 2021/0230633 A1Published application
Nucleotide vaccine
AssigneeCopenhagen University
InventorsPeter Johannes Holst, Allan Randrup Thomsen, Jan Pravsgaard Christensen
Life of this patent
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Abstract
The present invention relates to a vaccine comprising a nucleic acid construct such as a DNA construct especially a nucleic acid construct comprising sequences encoding invariant chain operatively linked to antigenic protein or peptide encoding sequences. The vaccine stimulates an immune response, especially an immune response in an MHC-I dependent, but CD4+ T-cell independent manner.
Claims11
1-185. (canceled)
An adenoviral vector comprising a nucleotide construct encoding:
- (a) at least one antigen derived from hepatitis C virus and
- (b) at least one invariant chain, wherein the invariant chain is directly linked to the at least one antigen by the last amino acid residue of the invariant chain sequence.
Dependencies are inferred from the claim text.