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US 2021/0230602 A1Published application
Composition for inhibiting ctgf expression
AssigneeLemonex Inc.
InventorCheol Hee WON
Life of this patent
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Abstract
A composition according to an embodiment of the present invention includes nucleic acid molecules which are capable of effectively inhibiting the expression level of connective tissue growth factor (CTGF) and collagen by RNA interference (RNAi), thereby preventing or treating a variety of fibroproliferative diseases due to overexpression of CTGF or collagen.
Claims16
A composition comprising a nucleic acid molecule comprising at least one selected from the group consisting of:
- siRNA comprised of a sense RNA having the sequence of SEQ ID NO:
- 1 and an antisense RNA having the sequence of SEQ ID NO:
- 2;
- dsRNA comprised of a strand having a sequence of SEQ ID NO:
- 3 and another strand complementary thereto;
- siRNA comprised of a sense RNA having a sequence of SEQ ID NO:
- 52 and an antisense RNA having a sequence of SEQ ID NO:
- 53;
- dsRNA comprised of a strand having a sequence of SEQ ID NO:
- 54 and another strand complementary thereto;
- siRNA comprised of a sense RNA having a sequence of SEQ ID NO:
- 55 and an antisense RNA having a sequence of SEQ ID NO:
- 56;
- dsRNA comprised of a strand having a sequence of SEQ ID NO:
- 57 and another strand complementary thereto;
- siRNA comprised of a sense RNA having a sequence of SEQ ID NO:
- 58 and an antisense RNA having a sequence of SEQ ID NO:
- 59;
- dsRNA comprised of a strand having a sequence of SEQ ID NO:
- 60 and another strand complementary thereto;
- siRNA comprised of a sense RNA having a sequence of SEQ ID NO:
- 61 and an antisense RNA having a sequence of SEQ ID NO:
- 62;
- dsRNA comprised of a strand having a sequence of SEQ ID NO:
- 63 and another strand complementary thereto;
- siRNA comprised of a sense RNA having a sequence of SEQ ID NO:
- 64 and an antisense RNA having a sequence of SEQ ID NO:
- 65;
- dsRNA comprised a strand having a sequence of SEQ ID NO:
- 66 and another strand complementary thereto;
- siRNA comprised of a sense RNA having a sequence of SEQ ID NO:
- 67 and an antisense RNA having a sequence of SEQ ID NO:
- 68;
- dsRNA comprised of a strand having a sequence of SEQ ID NO:
- 69 and another strand complementary thereto;
- siRNA comprised of a sense RNA having a sequence of SEQ ID NO:
- 70 and an antisense RNA having a sequence of SEQ ID NO:
- 71;
- dsRNA comprised of a strand having a sequence of SEQ ID NO:
- 72 and another strand complementary thereto;
- and PNA comprised of one sequence selected from the group consisting of sequences of SEQ ID NO:
- 87 to SEQ ID NO:
- 99.
40 more elements
Dependencies are inferred from the claim text.