Programmable conditional sirnas and uses thereof
AssigneesCity of Hope, California Institute of Technology
InventorsSi-ping HAN, William A. GODDARD, III, Marwa Ben HAJ SALAH, Lisa SCHERER, John J. ROSSI
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Abstract
Disclosed herein are programmable, conditionally activated small interfering RNA constructs (Cond-siRNAs) and methods of making and using the same as therapeutic agents. The Cond-siRNA comprises a sensor strand, a core strand, and a guide strand, which crossover to form a sensor duplex and a RNAi duplex attached to each other to form a single structure. Upon binding an input strand to the sensor strand, the Cond-siRNA is activated and releases RNAi targeting a desired gene.
Claims12
A programmable, conditionally activatable small interfering RNA (Cond-siRNA) construct comprising a sensor strand, a core strand, and a guide strand, wherein:
- (i) the sensor strand and the core strand form a sensor duplex,
- (ii) the guide strand and the core strand form a RNAi duplex, and
- (iii) the sensor duplex is attached to the RNAi duplex to form a single structure.
Dependencies are inferred from the claim text.