Targeted Self-Assembly of Functionalized Carbon Nanotubes on Tumors
AssigneeSloan-Kettering Institute for Cancer Research
InventorsDavid A. Scheinberg, Michael R. McDevitt, Carlos H. Villa, J. Justin Mulvey
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Abstract
Provided herein are single wall nanotube constructs to which are convalently linked a plurality of a bifunctional chelator, a therapeutic or a diagnostic radionuclide chelated to each bifunctional chelator and a plurality of morpholino oligonucleotides conjugated to the single wall nanotube. Also provided are single wall nanotube complexes which have the morpholino oligonucleotides on the single wall nanotube constructs hybridized to other morpholino oligonucleotides. The other morpholino oligonucleotides are each conjugated to a therapeutic antibody.
Claims14
A single wall nanotube construct, comprising:
- a plurality of a bifunctional chelator covalently linked to a single wall nanotube;
- a therapeutic or a diagnostic radionuclide chelated to each bifunctional chelator;
- and
- a plurality of morpholino oligonucleotides conjugated to the single wall nanotube.
Dependencies are inferred from the claim text.