Angiogenesis using stimulated placental stem cells
AssigneeCelularity Inc.
InventorsKathy E. KARASIEWICZ-MENDEZ, Aleksander FRANCKI, Jeffrey TURNER, Eric LAW, Jennifer PAREDES, Kristen LABAZZO, Hemlata RANA, Wolfgang HOFGARTNER, Robert J. HARIRI
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Abstract
Provided herein are stimulated placental stem cells and methods of treating individuals having diseases or disorders of the circulatory system using stimulated placental cells. The invention also provides methods of inducing angiogenesis using such stimulated cells or populations of cells comprising such stimulated cells.
Claims34
An isolated stimulated placental derived adherent cell, wherein said cell is adherent to tissue culture plastic, and wherein said cell is CD10+, CD34−, CD105+ and CD200+, wherein said cell has been contacted with one or more pro-inflammatory cytokines in vitro, and wherein said cell (1) promotes the proliferation of endothelial cells;
- (2) promotes the formation of sprouts or tube-like structures in a population of endothelial cells;
- or (3) promotes the migration of endothelial cells.
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A method of producing a stimulated placental derived adherent cell, wherein said cell is CD10+, CD34−, CD105+ and CD200+, the method comprising contacting a placental derived adherent cell with one or more pro-inflammatory cytokines in vitro.
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Dependencies are inferred from the claim text.