Human organ-on-chip models for predictive screening
AssigneeThe Trustees of Columbia University in the City of New York
InventorsGordana Vunjak-Novakovic, Keith Yeager, Kacey Ronaldson
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Abstract
An integrated modular microphysiological system is provided which includes a two or more chambers and a vascular network which includes at least one channel. The chamber can be configured for culturing a tissue and includes a layer of endothelial cells which forms an endothelial barrier within the well. The endothelial barrier can be in fluid contact with at least one of the at least one channels in the vascular network. The endothelial barrier can also be in fluid contact with a fluid in the chamber.
Claims20
An modular microphysiological system, comprising:
- two or more inserts defining a well formed by a wall portion surround the well and a bottom portion, the bottom portion having an opening and a permeable membrane positioned across the opening;
- and
- a platform having two or more chambers configured to receive said two or more inserts, wherein a flow channel is formed between the platform and the two or more inserts when inserts are inserted into said two or more chambers.
An integrated modular microphysiological system, comprising:
- two or more inserts disposed in two or more chambers defined in a platform,
- the two or more inserts defining a well formed by a wall portion surrounding the well and a bottom portion, the bottom portion having an opening and a permeable membrane positioned across the opening and an endothelial barrier disposed on the permeable membrane,
- wherein a flow channel is formed between the platform and the two or more inserted inserts.
Dependencies are inferred from the claim text.