Urethane-crosslinked biodegradable elastomers
AssigneesMassachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Biocant-Center of Innovation and Biotechnology
InventorsRobert S. Langer, Jeffrey M. Karp, Maria Jose Maio Nunes-Pereira, Ben Ouyang, Lino da Silva Ferreira, Debanjan Sarkar
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Abstract
Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B-)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.
Claims30
1-22. (canceled)
An implantable biodegradable elastomeric cross-linked polyester material comprising:
- a plurality of A and B components, wherein the A and B components form a plurality of polymeric backbones formed of (-A-B-) repeat units, having the general formula (-A-B-)p, wherein:
- p is an integer greater than 1;
- the (-A-B-) repeat units have a chemical structure produced by condensation of a polyol component A′ with a polyacid component B′;
- and
- one or more pharmaceutical agents;
- wherein the A component of at least two of the (-A-B-) repeat units within each of the polymeric backbones has at least one free hydroxyl group present thereon, prior to crosslinking;
- wherein crosslinking is carried out by a polyisocyanate crosslinker and the at least one free hydroxyl group to the polyisocyanate crosslinker at a molar ratio of between 1:0.1 and 1:1.5;
- and
- wherein urethane cross-links covalently crosslink the polymeric backbones between the A components of the at least two (-A-B-) repeat units within each of the polymeric backbones.
Dependencies are inferred from the claim text.