Antibody binding to axl protein and application thereof
AssigneesHangzhou Sumgen Biotech Co., Ltd., Sumgen Mab (Beijing) Biotech Co., Ltd.
InventorsMing LV, Xiaoran DING, Shiwei MlAO, Bin TAN, Xuegong WANG
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Abstract
Provided is an antibody or an antigen-binding fragment thereof, having one or more properties selected from the group consisting of: 1) being capable of binding to an AXL protein by a KD value of 1×10−8M or lower; 2) being capable of specifically recognizing an AXL protein expressed on a cell surface; and 3) being capable of mediating internalization after binding to the AXL protein expressed on the cell surface. The antibody may further used for constructing an immunoconjugate. The antibody and the immunoconjugate may inhibit the proliferation of tumor cells.
Claims60
An antibody, its antigen-binding fragment or variant with one or more properties selected from the group consisting of:
- 1) an ability of binding to an AXL protein with a KD value of 1×10−8 M or below;
- 2) an ability of specifically recognizing an AXL protein expressed on the surface of a cell;
- and
- 3) an ability of mediating internalization after binding to an AXL protein expressed on the surface of a cell.
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The antibody or its antigen-binding fragment according to 21, wherein said antibody light chain or its fragment comprises the amino acid sequence of SEQ ID NO:
- 12.
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Dependencies are inferred from the claim text.