Antibody complex and uses thereof
AssigneeDiatheva S.R.L.
InventorsValentina FIORI, Sabrina DOMINICI, Diego MORICOLI, Maria Elena LAGUARDIA, Cosimo Damiano CARBONELLA, Maria Cristina BALDUCCI
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AssigneeDiatheva S.R.L.
InventorsValentina FIORI, Sabrina DOMINICI, Diego MORICOLI, Maria Elena LAGUARDIA, Cosimo Damiano CARBONELLA, Maria Cristina BALDUCCI
Estimating the term…
The present invention relates to a multivalent, preferably bivalent, antibody complex, more preferably a diabody, i.e. a bivalent scFv, capable of recognizing and binding the human protein CD99, a composition comprising said complex and the use thereof for diagnostic purposes and/or for the treatment and/or the follow-up of leukaemias and/or myelodysplastic syndromes. Furthermore, the present invention relates to antibodies, preferably monoclonal, of the immunoglobulins G group type capable of recognizing and binding the human protein CD99, a composition comprising said immunoglobulins and the medical use thereof, in particular for the treatment and/or the follow-up of cancer, preferably solid tumours that express CD99 and/or leukaemias and/or myelodysplastic syndromes.
1-21. (canceled)
An isolated IgG type immunoglobulin capable of recognizing and binding an epitope of the extracellular domain of the human protein CD99, wherein said immunoglobulin comprises at least two variable regions capable of recognizing and binding an epitope of the extracellular domain of the human protein CD99 characterized by an amino acid sequence comprising SEQ ID NO:
Dependencies are inferred from the claim text.