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US 2021/0230285 A1Published application
Multispecific antibodies, compositions comprising the same, and vectors and uses thereof
AssigneeAprilBio Co., Ltd.
InventorSang Hoon CHA
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Abstract
The present disclosure provides a multispecific antibody having increased in vivo sustainability, the multispecific antibody comprising one or more bioactive effector moieties linked to either or both of an N-terminal and a C-terminal of an antigen binding fragment Fab that binds to human serum albumin.
Claims32
A multispecific antibody comprising a structural formula of:
- wherein the antigen binding fragment (Fab) is a serum albumin Fab;
- wherein R1 and R2 are bioactive effector moieties linked to an N-terminus of the Fab, each linked to a heavy chain variable domain or a light chain variable domain of the Fab;
- wherein R3 and R4 are bioactive effector moieties linked to a C-terminus of the Fab, each linked to a heavy chain variable domain or a light chain variable domain of the Fab;
- wherein m is 0 or an integer of 1 or greater;
- and
- wherein n is 0 or an integer of 1 or greater.
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An expression vector comprising:
- (a) a promoter,
- (b) a first nucleic acid molecule encoding an antigen binding fragment (Fab) that binds to serum albumin, and
- (c) a second nucleic acid molecule encoding a bioactive effector moiety and a linker,
- wherein the promoter, the first nucleic acid sequence, and the second nucleic acid molecules are operably linked.
1 more element
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Dependencies are inferred from the claim text.