Specific antibody-drug-conjugates (adcs) with ksp inhibitors and anti-cd123-antibodies

An antibody or antigen-binding antibody fragment that binds to CD123, comprising a variable heavy chain comprising the variable CDR1 sequence of the heavy chain, as shown in SEQ ID NO:

• 202, the variable CDR2 sequence of the heavy chain, as shown in SEQ ID NO:
• 203, and the variable CDR3 sequence of the heavy chain, as shown in SEQ ID NO:
• 204;
• and a variable light chain comprising the variable CDR1 sequence of the light chain, as shown in SEQ ID NO:
• 206, the variable CDR2 sequence of the light chain, as shown in SEQ ID NO:
• 207, and the variable CDR3 sequence of the light chain, as shown in SEQ ID NO:
• 208.