Anti-human interleukin 17a monoclonal antibody and application thereof
AssigneeJiangsu Qyuns Therapeutics Co., Ltd.
InventorsJiwan QIU, Zhihua QIU, Wei CHEN, Tao CHEN, Yong KONG, Yiliang WU
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Abstract
Disclosed by the present invention are an anti-human interleukin 17A monoclonal antibody and an application thereof. The epitope of the monoclonal antibody binding to human interleukin 17A comprises 78th asparagine (N78). The antibody may be used to treat rheumatoid arthritis, psoriasis, multiple sclerosis, psoriatic arthritis, plaque psoriasis and/or ankylosing spondylitis.
Claims18
1-18. (canceled)
An isolated anti-human interleukin 17A monoclonal antibody, which comprises three heavy chain complementarity determining regions (CDR-H1, CDR-H2 and CDR-H3) and three light chain complementarity determining regions (CDR-L1, CDR-L2 and CDR-L3), wherein,
- (a) an amino acid sequence of CDR-H1 is the amino acid sequence shown in SEQ ID NO:1;
- (b) an amino acid sequence of CDR-H2 is the amino acid sequence shown in SEQ ID NO:
- 2;
- (c) an amino acid sequence of CDR-H3 is the amino acid sequence shown in SEQ ID NO:
- 3;
- (d) an amino acid sequence of CDR-L1 is the amino acid sequence shown in SEQ ID NO:
- 4;
- (e) an amino acid sequence of CDR-L2 is the amino acid sequence shown in SEQ ID NO:
- 5;
- and
- (f) an amino acid sequence of CDR-L3 is the amino acid sequence shown in SEQ ID NO:6.
An isolated anti-human interleukin 17A monoclonal antibody, comprising a heavy chain variable region with an amino acid sequence shown in SEQ ID NO:7 and a light chain variable region with an amino acid sequence shown in SEQ ID NO:8.
An isolated anti-human interleukin 17A monoclonal antibody, which binds to an epitope including G75C76I77N78A79D80G81N82V83D84Y85 in human interleukin 17A.
Dependencies are inferred from the claim text.