Back to results
US 2021/0230263 A1Published application
Anti-Il-22 Antibodies, Antibody Fragments,Their Immunoconjugates And Uses Thereof
AssigneeBioAtla, Inc.
InventorsJay M. Short, Gerhard Frey, Hwai Wen Chang, William Boyle
Life of this patent
Estimating the term…
Abstract
An anti-IL-22 antibody or antibody fragment that binds to both human IL-22 and a mammalian IL-22 as well as modified anti-IL-22 antibodies and antibody fragments. Pharmaceutical compositions and kits comprising the antibody or antibody fragment are also provided. Also provided are methods for treatment of various IL-22 mediated conditions and diseases.
Claims36
An anti-IL-22 antibody or antibody fragment comprising:
- a light chain variable region including a light chain CDR1 having an amino acid sequence selected from SASSSVSX1MH (SEQ ID NO:1), a light chain CDR2 having an amino acid sequence selected from X2TX3KLX4S (SEQ ID NO:2), and a light chain CDR3 having an amino acid sequence of QQWSSNPYIT (SEQ ID NO:3);
- and
- a heavy chain variable region including a heavy chain CDR1 having an amino acid sequence selected from GYIFX5SYWIH (SEQ ID NO:4), a heavy chain CDR2 having an amino acid sequence selected from RIYPGTGX6TYYNX7KFKG (SEQ ID NO:5), and a heavy chain CDR3 having an amino acid sequence selected from SYX8X9SVX10Y (SEQ ID NO:6),
- wherein X1 is Y or K, X2 is E or K, X3 is S or R, X4 is A or L, X5 is T or R, X6 is N or R, X7 is E or R, X8 is D or M, X9 is S or Y, and X10 is A or G.
1 more element
(canceled)
(canceled)
(canceled)
An antibody or antibody fragment comprising:
- a light chain variable region having an amino acid sequence that has at least 90% sequence identity to one of amino acid sequences with SEQ ID NOS:
- 7-12;
- and
- a heavy chain variable region having an amino acid sequence that has at least 90% sequence identity to one of amino acid sequences with SEQ ID NOS:
- 13-18.
2 more elements
(canceled)
Dependencies are inferred from the claim text.